Selective modulation of P-glycoprotein-mediated drug resistance
نویسندگان
چکیده
منابع مشابه
Overcoming P-glycoprotein-Mediated Drug Resistance in Epilepsy
2. ABSTRACT More than 20 million epileptics worldwide do not respond to antiepileptic drugs. This is in part due to overexpression of the drug efflux transporter, P-glycoprotein, in capillaries of the blood-brain barrier. However, the mechanism signaling P-glycoprotein upregulation is unknown. Lack of this knowledge is an important clinical problem, because it limits successful treatment of pat...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 2001
ISSN: 0007-0920,1532-1827
DOI: 10.1054/bjoc.2001.2184